Seek a specialist review at Pulmovista Clinics immediately. Non-response to antibiotics at 48–72 hours is a clinical warning sign — it may indicate the wrong antibiotic for the organism, a resistant organism, the wrong diagnosis (TB, ABPA, viral infection, organising pneumonia), or a complication (lung abscess, empyema). Simply switching to a different antibiotic without investigation is not appropriate. At Pulmovista, non-response triggers a systematic review: repeat imaging, sputum culture, TB investigation, and clinical reassessment.